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Lions Mane

About Lion’s Mane

Science has been researching these mushrooms for decades. Below we’ve listed the main targets in Chaga research*.
Take notice: this list should not be interpreted as a list of medical claims ! For an extensive background click here  ( page opens in new window ).

Its immune-supporting potential

Oriveda’s L+ is an alcohol extract. Water-soluble beta-glucans are the main immune-supporting compounds in these mushrooms, but because L+ is an alcohol extract the level of beta-glucan is very low. If you want both immune-support and Lion’s Mane’s NGF-supporting effects you can consider adding CCCE® to your shopping bag.

CCCE® is a unique blend of 3 types of mushroom beta-glucan and includes a significant level of cordycepin; higher than 99.9% of Cordyceps extracts as a matter of fact. Combined with Lion’s Mane L+ you get a very potent combination – relevant for elderly people and people experiencing chronic stress in particular.

Its potential for Anti-Gastritis and Anti-Ulcer effects

Traditionally hot water-extracted Lion’s Mane was used to treat peptic ulcers and chronic gastritis. Please note L+ is an alcohol extract!

Improving cognitive functions and stimulating the Nerve Growth Factor

Nerve growth factor (NGF) is a secreted protein that is important for the growth, maintenance, survival and regeneration of nerve cells, and is considered critical for their survival. Without it, these nerve cells / neurons will die, causing both cognitive and motoric problems. The discovery of the NGF was in the 1950s, and the scientists responsible received the Nobel Prize in 1986 for this, when the importance of the NGF was finally aknowlegded. NGF prevents or reduces the degeneration of nerve cells such as caused by neurodegenerative diseases (e.g. Alzheimer’s) and aging.

Lion’s Mane was found to contain a class of compounds that stimulate the production of NGF, indirectly stimulating nerves to regrow. These compounds are all alcohol-soluble terpenes, and are seperated in Hericenones(found mainly in the fruiting body) and Erinacines(found mainly in the mycelium)

These are so far the only active substances found in natural products that can induce the production of the NGF. These bioactives therefore might have great potential for -indirectly- repairing neurological damage, improving intelligence (cognition) and reflexes and, even more significant, to help slowing down the development of neurodegenerative diseases such as Alzheimer’s.

We quote from a recent case study (duration: 16 weeks) performed with 50- to 80-year-old Japanese men and women diagnosed with mild cognitive impairment: […] At weeks 8, 12 and 16 of the trial, the [Lion’s Mane] group showed significantly increased scores on the cognitive function scale compared with the placebo group. The [Lion’s Mane] group’s scores increased with the duration of intake.[…] The results obtained in this study suggest that [Lion’s Mane] is effective in improving mild cognitive impairment.”

The full article can be read here.

Its potential effects on menopausal problems, depression, anxiety

The NGF-inducing bioactives in Lion’s Mane also appear to have an effect on other areas of the brain, including areas that are related to Rett syndrome and bipolar disorder. Menopausal problems also include a mental element. Stress and/or anxiety are usually a precipitating factor in all of these and might negatively affect the levels of NGF.

We quote from a recent case study (2010; duration: 4 weeks) performed with 30 women in the menopausal age: […] “Concentration”, “irritating” and “anxious” tended to be lower than the placebo group. Our results show that HE intake has the possibility to reduce depression and anxiety and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus.[…]”.

The full article can be read here

Side effects and safety

There are no known noteworthy side effects. Some very sensitive people might experience mild side effects, due to their genetic wiring.

Oriveda’s L+ has limited immune-supporting properties because it is low on beta-glucan. However, just like with other mushrooms, it should not be used together with immune-suppressants, like those prescribed after a transplant.

The blood sugar lowering effects can cause fatigue in those that are highly susceptible. In general these people are also very susceptible to e.g. caffeine and alcohol, or are diabetic. Taking the extract together with a sugar-containing liquid can neutralise this effect.

Hericium erinaceus, Lion’s Mane, BDNF, NGF (Nerve Growth Factor), erinacine, hericenone

* The statements on this page have not been evaluated by the FDA or the EFSA.
This product is not intended to treat, cure or prevent any disease.
Do not use this product instead of regular medication.

Why ORIVeDA ‘s L+ ?

Lion’s Mane contains several unique bioactive compounds not found in other mushrooms; in particular the NGF- and BDNF-inducing compounds. Those are the main reason most people choose Lion’s Mane as a supplement.

Those compounds are hericenones (only found in the fruiting body) and erinacines (only found in the mycelium). Both are part of the class of alcohol-soluble terpenes and meroterpenes (compounds which are part terpene and part polyphenol). Until now, not a single Lion’s Mane supplement specifying and guaranteeing those compounds existed.

In Oriveda’s L+ the emphasis is on exactly those compounds and their presence, percentage and bioavailability is guaranteed. Unlike other vendors we do not focus on beta-glucan or polysaccharides; for beta-glucan (immune-supporting compound) Oriveda has formulated a dedicated product; CCCE®.

Click here to see our authorized ‘Supplement Facts‘ label with all relevant specifications.

If you buy a Lion’s Mane supplement because it lists a high level of beta-glucans (or polysaccharides) you are not spending your money wisely. It makes more sense to choose a Lion’s Mane supplement that specifies/guarantees Lion’s Mane-specific compounds, right?

As said, in Lion’s Mane the quality markers are 2 specific groups of bioactive terpenes; these contain the NGF- / BDNF-inducing compounds in Lion’s Mane. Those compounds are known as hericenones (present in the fruiting body only – mero-terpenes) and erinacines (only found in the mycelium – di-terpenes).

Until now over 30 of these compounds have been identified in Lion’s Mane. It is impossible to test for all of those individually. With only a few exceptions there’s no standardised reference material available.

Quite a few research papers however describe in great detail how these compounds were discovered, isolated and quantified. The independent third party lab we use used this information to come up with a reliable way to measure / quantify these compounds. Check our COAThis level of detail makes L+ unique.

What also sets Oriveda’s L+ apart as a unique product is that it is the first and only Lion’s Mane alcohol extract. Only an alcohol extract contains a noteworthy amount of these compounds – they are strictly alcohol-soluble. When we were developing L+ we have tested dual extraction as well but this would have meant an unacceptable compromise. Levels of alcohol-soluble bioactives were low. In particular the mycelium had a very low yield of less than 0.1%.

Then there is the fact that Oriveda’s L+ contains both fruiting body and pure mycelium. There are no other Lion’s Mane products on the market containing pure mycelium, which is a major -and surprising- omission because the mycelium contains the most important NGF-inducers; erinacines (their NGF-promoting effect is up to 4 times stronger when compared against hericenones according to research).

The mycelium used was cultivated in liquid substrate, formulated using the latest research in order to produce a very high level of erinacines. It is the first time this technique was used succesfully outside a research facility. The results were excellent – at least 2 % erinacines are guaranteed.

After repeated alcohol extraction (to squeeze out all active compounds) the final product is 100% uncompromised Lion’s Mane extract, free of additives or flow agents.

It should be obvious Oriveda’s L+ is a better choice than a liquid alcohol ‘tincture’ because in such products the main element is alcohol, not Lion’s Mane. If you would allow the alcohol to evaporate the remaining deposit equals maybe 1 gram of powdered extract. Such products also do not / cannot guarantee any bioactives. Also see our FAQ for more info about tinctures and such.

* The statements on this page have not been evaluated by the FDA or the EFSA.
This product is not intended to treat, cure or prevent any disease.
Do not use this product instead of regular medication.